Examinando por Autor "Orellana Romero, Paula Michelle"
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- ÍtemAcceso AbiertoImpacto de la Tocilizumad sobre la depresión en pacientes con artritis reumatoide(Universidad Católica de Cuenca., 2023) Orellana Romero, Paula Michelle; Castillo Solano, Freddy Damián; 0705753374Depression is a mood disorder that occurs very frequently due to pathologies that interfere with the patient's daily life. The aim of this article is to review the literature on the impact of treatment with tocilizumab, an interleukin-6 antagonist, on depression in patients with rheumatoid arthritis. It was found that all patients presenting with this autoimmune disease at any time will develop depression. Regarding the association of rheumatoid arthritis with depression, biological processes have been established that are still not fully clarified. However, the advancement of science has been able to identify that the effects on brain structure and function produced by immunological alterations are present in both conditions, where these changes are correlated with neuropsychiatric symptoms. This study has shown that tocilizumab therapy has a favorable effect on criteria demonstrating the severity of depression in patients with rheumatoid arthritis