Examinando por Autor "Barros Narváez, Daniela Lorena"
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- ÍtemAcceso AbiertoLinfoma no Hodgkin y terapia biológica(Universidad Católica de Cuenca., 2024) Barros Narváez, Daniela Lorena; León Pesantez, María Isabel; 0107095291Non-Hodgkin's lymphoma (NHL) belongs to a group of malignant neoplasms originating in lymphoid tissues, primarily in the lymph nodes. NHL has different subtypes, including epidemiology, etiology, and clinical and genetic characteristics. NHL is the sixth most common cause of cancer-related death in the United States after breast, prostate, bladder, colorectal, and lung cancer; this review aims to describe the efficacy of biological therapy in NHL. Ten articles were used where monoclonal antibodies and chimeric antigen receptor T-cell therapy (CAR-T) were found to have an overall response rate (ORR) (of 54.7-91%), a complete response (17.2-69%) and a highly significant progression-free survival. It has been shown that there is efficacy in using different biological therapies in NHL, mainly using the monoclonal antibody known as rituximab in CD 20+ diffuse B-cell lymphoma and CAR-T in relapsed NHL. Biological therapy's most frequent adverse effects are neutropenia, anemia, thrombocytopenia, leukopenia, and lymphopenia.