Sede Azogues - Medicina
URI permanente para esta comunidadhttps://dspace.ucacue.edu.ec/handle/ucacue/88
Examinar
Examinando Sede Azogues - Medicina por Asesores "Bermeo Ortega, Juan Carlos"
Mostrando 1 - 1 de 1
- Resultados por página
- Opciones de ordenación
Ítem Acceso Abierto Actualización terapéutica en el manejo de cáncer de mama triple negativo. Revisión Sistemática(Universidad Católica de Cuenca., 2025) Abad Espinoza, Camila Estefanía; Bermeo Ortega, Juan Carlos; 0302224969Triple-negative breast cancer (TNBC) lacks hormone receptors and the HER2 receptor, presenting a biological aggressiveness that challenges clinical management. Despite the molecular diversity within TNBC, its classification has no significant application in clinical practice. Objective: To analyze the current therapeutic approaches for triple-negative breast cancer in terms of its responsiveness to treatment and its association with prognosis. Methodology: The research focuses on the global epidemiology of breast cancer, emphasizing TNBC. A comprehensive search strategy of scientific articles in various databases was employed, with defined inclusion and exclusion criteria. Results: Breast cancer is a global health issue, with TNBC being more aggressive and more prevalent among young women. A relationship is observed with environmental chemical substances and modifiable factors that influence the risk of developing it. TNBC is mainly treated with platinum-based chemotherapy despite its significant side effects. Conclusions: TNBC presents substantial clinical challenges due to its aggressiveness and lack of conventional therapeutic receptors. Current therapeutic approaches, such as chemotherapy with platinum compounds, have shown efficacy but carry considerable side effects. Keywords: triple-negative breast cancer, epidemiology, treatment, biomarkers, precision medicine
