Trabajos de Titulación - Biofarmacia
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- ÍtemAcceso AbiertoDescripción de las propiedades fisicoquímicas y biofarmacéuticas de diversas marcas comerciales de tabletas de 25 mg de carvedilol.(Universidad Católica de Cuenca., 2024) Orbe Martínez, Byron Humberto; Cárdenas Cordero, Janneth Fernanda; 105474985; García Calle, Anthony AlxanderIntroduction: Carvedilol has proven to be an effective and widely used drug in treating hypertension. It is a beta-adrenergic blocker that acts on beta receptors in the heart and blood vessels, resulting in a decrease in heart rate, reduction in the force of contractions of the heart muscle, and dilation of blood vessels. Objective: To determine the physicochemical and biopharmaceutical properties of various commercial brands of Carvedilol 25 mg tablets. Methodology: This research aims to conduct physicochemical and biopharmaceutical analyses on Carvedilol tablets and the methodology approach is experimental, cross-sectional, and prospective. Results: All the physicochemical and biopharmaceutical properties of Carvedilol 25 mg tablets in its different commercial brands were disclosed. Conclusion: The data collected in this research supports the idea that some physicochemical and biopharmaceutical characteristics met the described pharmacopeias while others did not
- ÍtemEmbargoProyecto de Titulación embargado con fines de publicación de impacto(Universidad Católica de Cuenca., 2024) Moscoso Lituma , Fabian Eduardo; Tigre Tigre, Luis Andres; Arteaga Sarmiento, Sandra Denisse; 0105260384; 0106856768
- ÍtemEmbargoResistencia a los antimicrobianos por enterobacterias a nivel de América Latina y el Caribe 2013-2023(Universidad Católica de Cuenca., 2024) Sarango Berru, Ary Sebastian; Ortiz Tejedor, Jonnathan Gerardo; 1900770122Introduction: Antimicrobial resistance is a global problem, also known as the silent pandemic, due to the increasing rate of multi-resistant and pan-resistant bacteria. Enterobacteria are important to this problem because they are the most common at the hospital and community level and can produce beta-lactamase enzymes that inhibit beta-lactam antibiotics. Objective: To report the beta-lactam antibiotics with the highest efficacy against beta-lactamase enzyme-producing enterobacteria and the incidence of these enterobacteria in Latin America from 2013 to 2023. Methodology: A systematic review was carried out using the PRISMA method and sources such as PAHO, SciELO, Redalyc, PubMed, and the Google Scholar metasearch engine, collecting 69 documents and maintaining seven based on the inclusion and exclusion criteria. Results: Based on the different studies, it was found that the enterobacteria with antimicrobial resistance and the highest incidence in hospitals are E. coli, K. pneumoniae, and Enterobacter spp., and the beta-lactam antibiotics with higher efficacy against beta-lactamase enzymes are Imipenem and Meropenem; however, it has also begun to lose its effectiveness, causing a more drastic alternative treatment to be recommended, such as colistin. Conclusion: In Latin American hospitals, a large number of cases of bacterial infections produced by enterobacteria with multi-resistance to beta-lactams can be observed, mainly caused by patient self-medication, which, despite efforts to control the sale of these medications, continues to exist a high rate of enterobacteria with Antimicrobial resistance (AMR).
- ÍtemAcceso AbiertoImplementación de sistema para el control de inventario del laboratorio de tecnología farmaceútica de la facultad de bioquímica y farmacia de la Universidad Católica de Cuenca(Universidad Católica de Cuenca., 2023) Johnson Peláez, Katherine Viviana; Vacuilima Villa, Lisseth Paola; Moncada Angulo, Ruth Elizabeth; 0106492523; 0106946668INTRODUCTION: In Ecuador, inventories are fundamental to satisfy operations and to obtain higher profits, better management, and planning. For this reason, this study aims to implement an inventory control system in the pharmaceutical technology laboratory because the manual handling of the inventory prevented its correct control and the development of other activities. OBJECTIVE: To implement an inventory control system in the pharmaceutical technology laboratory of the Faculty of Pharmacy and Biochemistry of the Catholic University of Cuenca. MATERIALS AND METHODS: The design of this research is qualitative. The descriptive method was used; the information utilized for the development is based on a manual inventory of the laboratory staff. RESULTS: The inventory control system is beneficial for the automation of the stock, which will help to analyze the procedures and regulations to be followed to obtain improvements. CONCLUSION: Implementing f an inventory control system is an essential step to optimize processes and improve the laboratory environment; it is through monitoring and management that the timely availability of resources can be ensured.
- ÍtemSolo MetadatosIdentificación de staphylococcus aureus en el área de hospitalización en el Hospital Aida León de Rodríguez Lara, Girón - Azuay(Universidad Católica de Cuenca., 2023) Caldas Caldas, Glenda Nicole; Puglla Macas, Elizabeth Tatiana; Ochoa Coronel, Eduardo Maciel; 0106030695; 1900872241Staphylococcus aureus is a microorganism that, due to its virulence and resistance to antibiotics, causes hospital and community diseases. The infections it causes generally occur in hospitalized patients, but also in healthy people, leaving severe consequences. Objective: To identify Staphylococcus aureus through microbiological tests from swabs in the hospitalization area of the Aida León de Rodríguez Lara Hospital. Methodology: The study was carried out on 50 samples taken from different surfaces in 7 hospital areas. The inclusion criterion was to consider the surfaces in more significant contact with the personnel working in the institution and with the patients, while the exclusion criterion was to consider the surfaces that are not in greater contact with the personnel working in the institution and with the patients. Results: From 50 samples taken from different hospital areas, 35 positive samples were identified as positive for Staphylococcus aureus, representing 70% of the samples by conventional microbiological techniques. Conclusion: The presence of Staphylococcus aureus was quantified by microbiological tests, and it was determined that the highest percentage of presence of this microorganism is in the isolation section of the hospitalization area; therefore, strict compliance with biosafety standards is recommended to avoid possible infections and complications in patients and staff.
