Examinando por Autor "Castillo Hurtado, Junior Bryan"
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Ítem Acceso Abierto Acrodermatitis enteropática: Diagnóstico y tratamiento(Universidad Católica de Cuenca., 2024) Castillo Hurtado, Junior Bryan; Espinoza Días, Cristobal Ignacio; 0850601154INTRODUCTION: Acrodermatitis enteropathica is an autosomal recessive disorder due to zinc deficiency due to an alteration in one of the zinc transporter families (ZnT and ZIP) responsible for its regulation. It presents a triad characterized by periorificial dermatitis, diarrhea, and alopecia in 20% of patients. The diagnosis is made by measuring plasma zinc levels with average values between 70 and 110 ug/dL. Values <50 ug/dL suggest suspicion of acrodermatitis enteropathica. Treatment is based on zinc supplementation at 10-15 mg/kg/day doses. OBJECTIVE: To develop a clear and structured bibliographic review to provide the tools for the opportune disease’s identification, correct diagnosis, and adequate treatment. METHODOLOGY: A literature review was conducted employing PubMed, SciELO, Elsevier, Redalyc, and Ebsco databases. RESULTS: The mean age of symptom onset was six months. For all cases, the male sex is the most affected (53%). In 100% of the cases, the patients presented periorificial and acral skin lesions; diarrhea was present at 44% and alopecia at43%. On the other hand, family history of acrodermatitis enteropathica and consanguinity were reported principally in Middle Eastern countries (22% and 40%). In 100% of the cases, zinc levels were determined below the reference values, and in 32% of the cases alkaline phosphatase was determined. Genetic studies confirm the SLC39A4 gene alteration (19%). Keywords: Acrodermatitis enteropathica, zinc, skin, zinc deficiency, intestinal absorption
