Trabajos de Titulación - Medicina
URI permanente para esta colecciónhttps://dspace.ucacue.edu.ec/handle/ucacue/23
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Examinando Trabajos de Titulación - Medicina por Asesores "Reibán Espinoza, Esteban Adrián"
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Ítem Acceso Abierto Células madre en el tratamiento del pie diabético(Universidad Católica de Cuenca., 2025) Romero Añazco, Paulo Darío; Reibán Espinoza, Esteban Adrián; 0706622941Diabetes mellitus represents a worldwide public health problem, with diabetic foot ulcers being a catastrophic complication causing infection, gangrene, and repeated hospitalizations. It is a challenging medical situation resulting from current ineffective therapy to prevent lower limb amputation, highlighting the need for complementary therapeutic options. One cutting-edge option is stem cell-based therapy that allows tissue regeneration, promotes angiogenesis, modulates the immune system, and offers a unique regenerative approach that, in early stages, demonstrates promising potential to improve wound and ulcer healing in patients with diabetes. The primary therapeutic option is mesenchymal stem cells, which enable cell renewal and avoid apoptosis of functional cells. However, the leading limitations include the risks of immunological rejection, high cost, and malignant degeneration, as well as the lack of standardized protocols and long-term safety. Their therapeutic potential derives from their ability to differentiate into various cell types responsible for healing, facilitate ulcer healing, and improve microcirculation, reducing the risk of infections and amputations. This enhances prognosis and quality of life and reduces serious complications associated with diabetic foot.Ítem Acceso Abierto Linfomas doble y triple HIT; como factor de mal pronóstico en Linfoma difuso de células B grandes(Universidad Católica de Cuenca., 2024) Urgiles Pacheco, María De Los Angeles; Reibán Espinoza, Esteban Adrián; 0105578694Introduction: Double- and triple-hit diffuse large B-cell lymphoma (DLBCL) is a hematological malignancy with a MYC, BCL 2, and/or BCL 6 gene rearrangement. Currently, these lymphomas have an incidence of 8% concerning all cases of DLBCL. Unfortunately, its prognosis is generally negative, with a one-year survival rate due to its high aggressiveness because of the conflicting genetic rearrangement and the difficult late diagnosis, treating this pathology as a simple non-Hodgkin lymphoma. Objective: The research aims to study the prognosis of double (DHL) and triple hit (THL) diffuse large B-cell lymphoma. Methodology: A narrative bibliographic review was conducted, collecting information and scientific evidence through the biomedical database PubMed, especially updated English articles from the last five years. Results: This research aimed to demonstrate with scientific information the extremely unfavorable prognosis in patients with double- and triple-hit lymphoma, as well as a low overall survival rate and progression-free survival.Ítem Acceso Abierto Manejo de la leucemia promielocítica aguda en recaída(Universidad Católica de Cuenca., 2025) Zhunio Pérez, Jennifer Valeria; Reibán Espinoza, Esteban Adrián; 0107230336Acute promyelocytic leukaemia has become the most manageable form of myeloid leukaemia, with significantly high survival rates, however approximately one tenth of patients experience a relapse, which is why it is important to know the first-line therapeutic background for the accurate choice of an optimal early therapeutic strategy. Several factors are considered in the choice of therapeutic intervention such as risk stratification based on leukocyte count, remission time, comorbidities, mutations and APL variants that influence prognosis and overall survival. Quarterly monitoring within the first three years after first remission is crucial as this is a period of high susceptibility to relapse. Initial therapeutic selection is the determining factor in achieving complete disease remission and preventing relapse. In the latter, additional administration of anthracyclines and gemtuzumab-ozogamicin to transretinoic acid therapy with arsenic trioxide ensures the first phase of treatment, autologous haematopoietic stem cell transplantation in the consolidation phase, and allogeneic transplantation is used as a second alternative to the latter. Autologous transplantation and arsenic trioxide play a key role in relapse therapy, their efficacy leading to higher disease-free survival rates and lower mortality rates.Ítem Embargo Marcadores moleculares de mal pronóstico en la leucemia mieloide aguda(Universidad Católica de Cuenca., 2024) Arce López, Dayana Marcela; Reibán Espinoza, Esteban Adrián; 0350066361Ítem Acceso Abierto Síndrome de Heyde asociado al factor de Von Willebrand(Universidad Católica de Cuenca., 2024) Cárdenas Andrade, Gabriel Joseph; Reibán Espinoza, Esteban Adrián; 0107130379Introduction: Heyde's syndrome is a disorder that was described for the first time in 1958. This disorder can cause high mortality and morbidity rates if the correct diagnosis is not made. Objectives: Bring up an approach of Heyde Syndrome to focus the attention of different researchers and provide a compilation of updated information for a better understanding of the topic. Methods: Articles such as Meta-Analysis, Bibliographic Reviews, Systematic Reviews and clinical tests were taken in consideration for this article, leaving behind articles that did not meet the inclusion criteria mentioned before. MeSH terms such as: "Aortic stenosis AND Gastrointestinal AND Hemorrhage AND Syndrome AND Von Willebrand” were used for the search. Results: Heyde's syndrome usually occurs at advanced ages, there are not enough studies, therefore there is no data for this disorder, making it difficult to diagnose. Aortic stenosis in Heyde's syndrome is a key finding when it is accompanied by gastrointestinal bleeding. Demonstrating that aortic stenosis is related to metalloprotease activity producing a Von Willebrand proteolysis. Conclusion: Heyde's syndrome is a complicated pathology, with characteristic signs and symptoms such as aortic stenosis, gastrointestinal bleeding and anemia. Surgically placed or transcatheter prostheses can improve the severity of this pathology, especially in patients with advanced aortic stenosis.
