Examinando por Autor "Cajamarca Guichay, Evelyn Ximena"
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- ÍtemAcceso AbiertoEfectividad de denosumab versus bifosfonatos en mujeres post menopáusicas con Osteoporosis. Revisión Sistemática(Universidad Católica de Cuenca., 2024) Cajamarca Guichay, Evelyn Ximena; Fernández Verdugo, Joselyne Viviana; Capote Llanares, Miguel Angel; 0105580013; 0302200464Background: Osteoporosis is a skeletal disease characterized by a decrease in bone mineral density, causing an increase in bone fragility and fractures. In postmenopausal women, there is a decrease in estrogen and, in turn, an increase in osteoclast activity, producing a change in bone microstructure. Objective: To determine the effectiveness of Denosumab versus bisphosphonates as a treatment for Osteoporosis in postmenopausal women through a literature review. Methodology: A systematic review based on the PRISMA 2020 method was conducted. Studies published in the last five years in English and Spanish related to Denosumab and bisphosphonates treatment were included, using databases such as Scopus, SciELO, and Web of Science. Studies older than five years and those not from reliable sources were excluded. The results were synthesized using the National Heart, Lung, and Blood Institute (NHLBI) quality assessment scale to determine the quality of studies, and the risk of bias was evaluated individually employing the Cochrane tool. Results: Nineteen studies were included: 6 from Web of Science, 12 from Scopus, and one from SciELO; additionally, five articles from randomized clinical studies and 14 meta-analyses were also incorporated. Discussion: A similarity in the effectiveness of Denosumab versus bisphosphonates was demonstrated in women with postmenopausal Osteoporosis. Limitations: Number of articles used. Other: Self-funded. Keywords: bisphosphonates, denosumab, post menopause, osteoporosis